NFL Predictions Week 6: Best Bets & Odds for Monday Night Football

Last Updated: October 12, 2025 8:29 PM EDT • 1 minute read X Social Google News Link

Our NFL predictions cover every game in Week 6 with our best NFL picks for game predictions, player props, parlay picks, and touchdown scorer predictions. We have you covered through the rest of this week's slate with another Monday Night Football doubleheader featuring Falcons vs. Bills and Bears vs. Commanders.
🏈 NFL predictions for Week 6
- Bills vs. Falcons prediction
- Bills vs. Falcons player props (coming soon)
- Bills vs. Falcons parlay picks (coming soon)
- Bills vs. Falcons anytime touchdown scorer predictions (coming soon)
- Bills vs. Falcons first touchdown scorer predictions (coming soon)
- Bills vs. Falcons expert picks (coming soon)
- Bears vs. Commanders prediction
- Bears vs. Commanders player props (coming soon)
- Bears vs. Commanders parlay picks (coming soon)
- Bears vs. Commanders anytime touchdown scorer predictions (coming soon)
- Bears vs. Commanders first touchdown scorer predictions (coming soon)
- Bears vs. Commanders expert picks (coming soon)
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💰 NFL odds & expert picks: Monday Night Football
Live NFL odds for every Week 6 game; updated in real time.
📊 Bills vs. Falcons odds
- Date: Monday, Oct. 13
- Kickoff: 7:15 p.m. ET
- Location: Mercedes-Benz Stadium (Atlanta)
- How to watch: ESPN
🔮 Bills vs. Falcons prediction
🦬 Over 49.5 (-118)
The Falcons should do their part to push the total over 49.5 points, too, as they have a favorable matchup on the ground with Bijan Robinson and Tyler Allgeier facing a Bill defense with the third-worst DVOA against the run and fourth-worst EPA per run.
- via Gary Pearson's Bills vs. Falcons prediction
📊 Bears vs. Commanders odds
- Date: Monday, Oct. 13
- Kickoff: 8:15 p.m. ET
- Location: Northwest Stadium (Landover, Md.)
- How to watch: ESPN
🔮 Bears vs. Commanders prediction
⬆️ Over 50 (-109)
This play is mostly about the Bears' defense. It’s allowing 29.3 points per game, fifth-most in the NFL, and has given up at least 24 points in three of four games. One of those performances came against the Raiders, who are averaging just 16.6 points per game.
- via Philip Wood's Bears vs. Commanders prediction
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