NFL Odds for Week 5: Betting Lines, Spreads & Totals for Every Game

📊 NFL odds Week 5, 2025

The NFL odds for Week 5 are via bet365.

Even with four teams on bye, our NFL picks are plenty loaded. Week 5 sees the Atlanta Falcons, Chicago Bears, Green Bay Packers, and Pittsburgh Steelers on the sideline.

• An NFC showdown features in the Thursday Night Football odds, with the Rams an 8.5-point home betting favorite over the 49ers; kickoff is at 8:15 p.m. ET (Prime Video)
• The league stays in Europe as Sunday opens with the Vikings a 3.5-point betting favorite over the Browns at Tottenham Hotspur Stadium in London (9:30 a.m. ET, NFL Network)
• The Sunday Night Football odds look like a blowout in the making as the Bills (-8) take on the Patriots (8:20 p.m. ET, NBC)
• The Monday Night Football odds project a tighter game than once imagined, with the Jaguars a 3.5-point underdog to the visiting Chiefs ahead of kickoff at 8:15 p.m. ET (ABC/ESPN)

📈  Week 5 biggest line movement

• The Rams moved from -3.5 to -5.5 following another strong showing, and to -8.5 as a number of 49ers have been ruled out
• Following a brutal showing from QB Carson Wentz and a decent showing from the Browns defense, the total for Minnesota-Cleveland has dropped from 38.5 to 36
• The Ravens have moved from -9.5 to +1.5 with news that Lamar Jackson will be sidelined; the total dropped from 43.5 to 40.5 on the news
• The Panthers and Dolphins have swapped favorite status regularly this week, with the Dolphins currently lined as a 1-point road favorite
• While the Bills should still win their AFC East clash with the Patriots, the line tightened from -10 (the only double-digit opener) to -8 following a scare for Buffalo against New Orleans

🚑 NFL Week 5 injury roundup

Here are the injuries we'll be watching entering Week 5, and how they may impact the odds and betting lines:

• Giants WR Malik Nabers (knee) is expected to miss the entire season
• Dolphins WR Tyreek Hill (knee) is expected to miss the entire season, and maybe next
• Ravens QB Lamar Jackson (hamstring) is expected to miss several weeks
• Ravens OL Ronnie Stanley (ankle) was forced out of the game against the Chiefs and is expected to undergo further testing
• Ravens CB Marlon Humphrey (calf) and LB Roquan Smith (hamstring) are expected to miss Week 5
• Cowboys RB Miles Sanders (ankle) had to leave the game last week but is expected to be able to suit up against the Jets
• Lions CB D.J. Reed (hamstring) may be placed on injured reserve, while CB Terrion Arnold (shoulder) may be able to suit up in Week 5 despite suffering injury
• Packers DL Devonte Watt (knee) was forced out and and unable to return; CB Nate Hobbs (head) suffered a concussion
• Jaguars DE Travon Walker (wrist) is expected to be held out of play for a period of time, but his injury is not considered season-ending; S Eric Murray (neck) was also forced from the game
• Chargers OL Joe Alt (ankle) suffered a likely high ankle sprain and will miss multiple weeks
• Vikings OL Brian O'Neill (knee) and C Ryan Kelly (head) were forced out and could miss more time

🏈 49ers vs. Rams odds: Thursday Night Football

• Kickoff: 8:15 p.m. ET from SoFi Stadium (Inglewood, Calif.)
• How to watch: Prime Video

🏈 Vikings vs. Browns odds: NFL London Game

• Kickoff: 9:30 a.m. ET from Tottenham Hotspur Stadium (London)
• How to watch: NFL Network
• Vikings vs. Browns early prediction

🏈 Patriots vs. Bills odds: Sunday Night Football

• Kickoff: 8:20 p.m. ET from Highmark Stadium (Orchard Park, N.Y.)
• How to watch: NBC
• Patriots vs. Bills early prediction

🏈 Chiefs vs. Jaguars odds: Monday Night Football

• Kickoff: 8:15 p.m. ET from EverBank Stadium (Jacksonville, Fla.)
• How to watch: ABC/ESPN
• Chiefs vs. Jaguars early prediction

🔢 NFL Week 5 odds and lines

There's an advantage to betting early NFL odds when attempting to beat the closing line. The closer you wait until kickoff to make your NFL picks, the harder it becomes to identify edges and secure the best price on most sides or totals.

❓NFL odds FAQs

Who's playing on prime time in Week 5?

The 49ers visit the Rams on Thursday Night Football, while the Bills host the Patriots on Sunday Night Football. Sunday action opens with an International Series game as the Vikings and Browns clash in London, and the week closes with the Chiefs and Jaguars on Monday Night Football.

How do NFL spread odds work?

When betting on the NFL, the favorite needs to win by a certain number of points to cover the "point spread" - also known as the betting line. Conversely, the underdog needs to lose by fewer than the points displayed in the spread or win outright to cash. For example, a 3-point favorite would need to win by more than a field goal to reward bettors.

How do NFL moneyline odds work?

When betting on the NFL, the underdog will have the "longer" odds and is typically priced at "plus-money" odds that indicate the profit on a $100 bet. For example, a team with +150 odds would turn a $100 bet into a $150 profit - or a $10 bet into a $15 profit - according to our odds converter.

Where can I find the NFL betting odds?

Shop around our best NFL betting sites to find the best odds for your college football picks. Our best sports betting sites for all sports include BetMGM, bet365, Caesars, FanDuel, and DraftKings.